Respiratory morbidity in infants born with a Congenital Lung Malformation
The actual frequency of respiratory symptoms related to congenital pulmonary malformations (CPMs) remains undetermined.
The aim of the study was to prospectively evaluate the respiratory symptoms occurring in infants with prenatally diagnosed CPMs, identify factors associated with the occurrence of these symptoms, and evaluate their resolution after surgery.
Eighty-five children were followed up to the mean age of 2.1±0.4 years. 6 patients underwent surgery during the first 28 days of life.Of the 79 remaining children, 42% had respiratory symptoms during infancy before any surgery. Wheezing was the dominant symptom and only one infant had documented infection of the cystic lobe. Symptoms were more frequent in children with non-cystic and hyperlucent CPMs. Sixty-six children underwent surgery during the follow-up period, and 40% of them displayed symptoms after the intervention. Six children had documented pneumonia during the postoperative period. Authors concluded thatCPMs are frequently associated with wheezing episodes
Surgery had no significant impact on these symptoms but was associated with a paradoxical increase in pulmonary infections, as well as an increased risk of pectus excavatum after thoracotomy.
Ref: Celine Delestraine et al. Pediatrics 2017; 1 39 (3): 1-10.