Phenotypes of sleep-disordered breathing symptoms to two years of age based on age of onset and duration of symptoms.
The primary objective of this study is to identify and characterize the different SDB phenotypes to two years of age in 770 children analyzed to identify SDB phenotypes using sleep-related breathing disorder (SRBD) scale.
Based on the sleep-related breathing disorder (SRBD) scale, a 22-item questionnaire that includes for example snoring, excessive daytime sleepiness, attention deficit hyperactivity disorder (ADHD), etc., the authors identified four different trajectories of sleep disordered breathing symptoms (SDB):
- No SDB
- Early onset SDB
- Late onset SDB
- Persistent SDB
For each trajectory some unique risk factors have been identified, with rhinitis and prior daycare attendance associated with all SDB trajectories.
Children prescribed GERD medication were more likely to present with early or late SDB symptoms. Children with a maternal history of OSAS were more likely to present with late or persistent SDB symptoms. Atopic children were more likely to present with persistent SDB symptoms. Late premature infants were more likely to present with late SDB. These findings suggest that different risk factors are associated with different phenotypes as represented by the age of onset and duration of SDB symptoms.
In conclusion, study results suggest that childhood SDB may not be a homogenous disorder. Rather, childhood parent-reported SDB may represent multiple overlapping phenotypes.
Kamal M, Tamana SK, Smithson L et al. ; Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators. Phenotypes of sleep-disordered breathing symptoms to two years of age based on age of onset and duration of symptoms. Sleep Med. 2018 Aug;48:93-100.