Focus area: Physicians
Low – moderate dose inhaled corticosteroids by and leukotriene receptor antagonists compared in patients with pre-school wheezing and asthma
Which is the best therapy?
Most international guidelines recommend that children ≤5 years with asthma or recurrent wheezing be treated with daily low - moderate dose inhaled corticosteroids (ICS) as the preferred controller and leukotriene receptor antagonists (LTRA) as alternative therapy. However, there is no systematic review of the efficacy of ICS monotherapy versus LTRA in this age group. A review of this topic was published in Pediatric Pulmonology in December.
Twenty-nine clinical studies have been identified. These studies shown that ICS therapy has been associated with better symptom control, fewer exacerbations and emergency room access for exacerbations compared to LTRA.
“Daily inhaled corticosteroids or montelukast for preschoolers with asthma or recurrent wheezing: A systematic review” di Castro-Rodriguez JA, Rodriguez-Martinez CE, Ducharme FM. Pediatric Pulmonology 2018 Dec;53(12):1670-1677.