Obstructive sleep apnea is associated with use of assisted ventilation among children with bronchopulmonary dysplasia hospitalized with respiratory illness: a nationwide inpatient cohort

The authors retrospectively evaluated data from hospital discharge records of the Kid's Inpatient Database for children

Among 33,640 hospitalizations of children with BPD for acute respiratory illness, there were 607 (1.8%) cases with comorbid OSA vs. 33,033 (98.2%) controls without OSA. Data showed that patients with OSA were more likely to have aspiration pneumonia, central sleep apnea, obesity, laryngeal stenosis, congenital airway, and skull/face/jaw anomalies. Multivariable regression showed that OSA was associated with invasive mechanical ventilation (OR 1.45, 95% CI 1.09-1.94, p = 0.012) and noninvasive mechanical ventilation (OR 2.61, 95% CI 1.71-3.98, p < 0.001), but not length of hospital stay or cost of hospitalization.

The authors concluded that In BPD patients hospitalized with acute respiratory illness, having OSA is associated with increased risks for respiratory insufficiency requiring noninvasive or invasive mechanical ventilation. Clinicians should therefore consider OSA, along with other BPD-associated comorbidities, in the management of this peculiar population.

REFERENCE
Po-Yang Tsou, Lystra P Hayden. Obstructive sleep apnea is associated with use of assisted ventilation among children with bronchopulmonary dysplasia hospitalized with respiratory illness: A nationwide inpatient cohort. Sleep Med. 2023 Sep;109:181-189. doi: 10.1016/j.sleep.2023.06.030. Epub 2023 Jul 7.